Description
Thymosin Alpha-1 | 99%+ Pure Research Peptide
Advance immune-biology and host-defense research with Thymosin Alpha-1 (TA1), a synthetic replica of a thymus-derived peptide produced at ≥99% purity. TA1 is investigated for its roles in T-cell maturation, dendritic-cell activation, and immune set-point regulation, supporting studies that span infection models, vaccine responsiveness, oncology-adjacent immunity, and healthy-aging pathways.
Key Features
- ≥99% Purity (HPLC/MS Verified) — Consistent, reproducible material for rigorous protocols
- Immune Modulation Focus — Explore T-cell function, antigen presentation, and cytokine balance
- Broad Research Utility — Infection, vaccine-response, oncology-adjacent, cardiometabolic, and neuro-immune models
- GMP-Compliant, USA-Made — Batch-to-batch reliability
- COA Included — Full lot-level documentation
What Is Thymosin Alpha-1?
Thymosin Alpha-1 (TA1, thymalfasin) is a 28-amino-acid peptide historically associated with the thymic microenvironment. In research settings, it is used to interrogate adaptive immunity (e.g., T-cell priming, memory) and innate pathways (e.g., dendritic-cell readiness), making it a useful tool compound for immune-system modeling.
Mechanism of Action (Research Context)
- T-Cells: Investigated for supporting maturation, clonal expansion, and effector/memory balance
- Dendritic Cells: Studied for enhancing antigen presentation and co-stimulatory signaling
- Immune Set-Point: Evaluated for bidirectional modulation—bolstering defense under load while tempering excessive responses in over-activation models
Research Highlights
- Immune Modulation & Vaccinology: Literature explores TA1 as a means to study vaccine responsiveness (especially with inactivated antigens), cytokine profiles, and host-defense markers in severe infection models.
- Oncology-Adjacent Immunity: Preclinical/clinical investigations assess TA1 as an adjunct to standard regimens, focusing on tumor–immune dynamics, T-cell readiness, and treatment tolerance in controlled protocols.
- Hepatic & Viral Models: Extensively researched in hepatitis cohorts for effects on immune regulation and as a companion to antiviral strategies (research framing varies by jurisdiction).
- Neuro-Immune & CNS: Animal studies report signals in neuroinflammation, neuronal support markers, and cognitive endpoints under inflammatory load.
- Antifungal Host Defense: Examined for dendritic-cell maturation and Th-helper activation in invasive fungal models.
- Cardiometabolic & Vascular: Early work explores effects on ACE-related pathways and cardiometabolic markers (mechanistic and translational research ongoing).
- Pain & Inflammation: Investigated for modulation of inflammatory pain mediators in chronic-inflammation paradigms.
- Mucosal/Dental & Tissue Repair: Exploratory studies in periodontal healing and post-trauma recovery models.
Note: Human evidence and regulatory status vary by country and indication. Results from specific clinical contexts may not generalize to all settings. More randomized, controlled human studies are warranted.
Specifications
- Identity: Thymosin Alpha-1 (Thymalfasin)
- Sequence: Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Lys-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu-Asn-Thr-Thr-Lys-Asp-Leu-Lys-Glu
- Molecular Weight: ~3108.3 g/mol
- CAS Number: 62304-88-7
- Appearance: White to off-white lyophilized powder
- Form & Sizes: Common research vials (e.g., 2 mg, 5 mg, 10 mg); custom sizes upon request
- Purity: ≥99% (HPLC/MS verified)
- Manufacturing: GMP-compliant facility, USA
- Storage: −20 °C, desiccated; protect from light
- Documentation: Certificate of Analysis (COA) included
Research Applications
- Immune System Modeling: T-cell/dendritic-cell function, cytokine balance, immune set-point
- Infection & Vaccine Studies: Host-defense markers, responder analyses, adjuvancy paradigms
- Oncology-Adjunct Frameworks: Tumor–immune crosstalk, tolerance/quality-of-life endpoints (research only)
- Neuro-Immune & CNS: Neuroinflammation and resilience markers under stressors
- Cardiometabolic: Vascular and enzymatic pathway exploration (e.g., ACE-related signals)
- Mucosal/Dental & Tissue Repair: Periodontal and epithelial-repair models
