Description
MS-31 Peptide (Elamipretide) | 99%+ Purity
Advance mitochondrial biology and bioenergetics research with MS-31 (also known as Elamipretide / MTP-131), a cell-permeable, mitochondria-targeted tetrapeptide produced at ≥99% purity. MS-31 is investigated for selective interaction with cardiolipin in the inner mitochondrial membrane, enabling studies of electron transport efficiency, ROS balance, and mitochondrial dynamics across diverse preclinical models.
Key Features
- ≥99% Purity (HPLC/MS Verified) — Consistent lots for reproducible protocols
- Mitochondria-Targeted — Cationic–aromatic motif studied for cardiolipin binding and cristae stabilization
- Bioenergetics Focus — Explore ATP production, redox signaling, and oxidative stress markers
- Cross-Model Utility — Cardiac, skeletal muscle, neuro, renal, and retinal research frameworks
- GMP-Compliant, USA-Made — Batch-to-batch reliability
- COA Included — Full analytical documentation with every vial
Mechanistic Overview (Research Context)
Mitoshield-31 is a tetrapeptide (D-Arg–dimethylTyr–Lys–Phe–NH₂) designed to concentrate within mitochondria and associate with cardiolipin, a signature phospholipid of the inner mitochondrial membrane. In preclinical studies, this interaction is investigated for:
- Optimizing Electron Transport: Assessing effects on complex function and coupling efficiency
- ROS/Redox Modulation: Evaluating oxidative stress markers and antioxidant responses
- Cristae Integrity & Dynamics: Imaging-driven analyses of mitochondrial structure and turnover
- Cytochrome c Interactions: Probing apoptosis-related signaling in stress models
Specifications
- Identity: (Elamipretide, MTP-131; synonym: Bendavia)
- Sequence (one-letter): r-D-Arg–Dmt (2’,6’-dimethyl-Tyr)–Lys–Phe–NH₂
- Molecular Weight: ~639.8 g/mol
- CAS Number: 736992-21-5
- Appearance: White to off-white lyophilized powder
- Purity: ≥99% (HPLC/MS verified)
- Form & Sizes: Common research vials 10 mg)
- Manufacturing: GMP-compliant facility, USA
- Storage: −20 °C, desiccated; protect from light; allow to reach room temp in a desiccator before opening
- Documentation: Certificate of Analysis (COA) included
Research Applications
- Cardiac & Ischemia–Reperfusion Models — Bioenergetic recovery, ROS markers, contractile indices
- Skeletal Muscle & Fatigue — Mitochondrial efficiency, endurance/fatigue endpoints, calcium handling
- Neurobiology — Mitochondrial stress, synaptic energy demand, redox signaling in CNS models
- Renal & Hepatic Stress — Oxidative injury paradigms and mitochondrial resilience markers
- Ophthalmic/Retinal — Photoreceptor/optic models assessing mitochondrial function and survival
- Aging & Metabolic Research — Mitochondrial turnover (mitophagy/biogenesis) and functional readouts
Any translational implications remain investigational. Outcomes vary by model, conditions, and endpoints. Additional well-controlled studies are warranted. For reseach use only.