Description
Melanotan II (MT-II) | 99%+ Purity
Advance pigmentation and melanocortin-axis research with Melanotan II (MT-II), a cyclic α-MSH analogue produced at ≥99% purity. MT-II is investigated as a melanocortin receptor agonist (primarily MC1R/MC4R) for studies spanning melanogenesis, UV/photobiology, energy balance, and neuroendocrine signaling. Research Use Only. Not for human consumption.
Key Features
- ≥99% Purity (HPLC/MS Verified) — Consistent lots for reproducible results
- Melanocortin Agonist — MC1R/MC4R engagement for pigmentation and appetite/energy signaling models
- Photobiology Focus — Supports assays of melanocyte cAMP signaling and UV-response endpoints
- Protocol Friendly — Lyophilized, research-grade format for precise dosing and method development
- GMP-Compliant, USA-Made — Batch-to-batch reliability
- COA Included — Full lot documentation
Mechanistic Overview (Research Context)
Melanotan II is a cyclic heptapeptide analogue of α-melanocyte-stimulating hormone (α-MSH) that activates melanocortin receptors:
- MC1R (Pigmentation Biology): Increases cAMP in melanocytes → interrogate pathways for melanin synthesis, melanosome transport, and DNA-damage response models.
- MC3R/MC4R (Neuroendocrine/Metabolic): Explore appetite regulation, energy homeostasis, and sexual-function signaling in preclinical systems.
- Immuno-Modulatory Angles: Melanocortin pathways are also studied for effects on inflammatory tone and cutaneous immune signaling.
Specifications
- Identity: Melanotan II (MT-II) — cyclic α-MSH analogue
- Synonyms: MT-II, Melanotan-2
- CAS Number: 1036322-26-5
- General Structure: Ac-Nle-cycloAsp−His−D−Phe−Arg−Trp−LysAsp-His-D-Phe-Arg-Trp-Lys-NH₂ (lactam bridge)
- Molecular Weight: ~1024.2 g/mol
- Appearance: White to off-white lyophilized powder
- Purity: ≥99% (HPLC/MS verified)
- Form & Sizes: Common research vials 10 mg
- Manufacturing: GMP-compliant facility, USA
- Storage: −20 °C, desiccated; protect from light
- Documentation: Certificate of Analysis (COA) included
Research Applications
- Pigmentation & Photobiology: Melanogenesis assays, UV-response and photoprotection markers, melanocyte signaling
- Metabolic/Neuroendocrine: Appetite/energy-balance pathways (MC3R/MC4R), exploratory sexual-function signaling
- Dermal/Inflammatory: Cutaneous immune modulation and cytokine readouts tied to melanocortin activity
- Comparative Receptor Pharmacology: MC1R vs. MC4R selectivity, potency, and downstream transcriptional signatures
Note: Translational relevance varies by model and endpoint; additional controlled studies are warranted to define safety, dosing, and efficacy parameters in new contexts.